Present Position

• From 01.12.2014 Consultant Gynaecologist, Subspecialist in Reproductive Medicine and Surgery, Central Manchester NHS Foundation Trust. Hon Senior Lecturer, University of Manchester
• I work as a consultant in a university teaching hospital and participate in a large NHS IVF service. I operate on patients with endometriosis, pelvic adhesions, menstrual dysfunction and fertility problems, with an emphasis on minimal access reproductive surgery. I provide emergency gynaecology and early pregnancy care to a large and diverse population. I am active in the training of junior doctors and an RCOG-accredited subspecialty trainee in reproductive medicine.

Qualifications

• 2012 F.R.C.O.G
• 2001 M.D., Bristol University, U.K.
• 1994 M.R.C.O.G.
• 1990 M.D., Pondicherry University, India
• 1987 M.B., B.S., Madras University, India

Previous Posts

• 20.10.03 to 30.11.2014 Consultant Gynaecologist, Subspecialist in Reproductive Medicine and Surgery, Addenbrookes’ Hospital, Cambridge. I was Clinical Director for Gynaecology from April 2009 to June 2012. I was the HFEA Person Responsible for Cambridge IVF
• 1.2.03 – 20.10.03 Locum Consultant Obs and Gynae, Addenbrooke’s Hospital,
• 1.11.02 – 31.1.03 Specialist Registrar, Obstetrics and Gynaecology, Addenbrooke’s Hospital, Cambridge
• 1.11.00 – 31.10.02 Subspecialty Trainee, Reproductive Medicine, , Addenbrooke’s Hospital, Cambridge
• This post provided an RCOG-approved training programme covering all areas for accreditation as a subspecialist in Reproductive Medicine.
• 1.11.99 – 31.10.00 Specialist Registrar, Obstetrics and Gynaecology Musgrove Park Hospital, Taunton
• 1.7.95 – 30.10.99 Clinical Research Fellow Bristol University Centre for Reproductive Medicine
• 1.5.94 – 30.6.95 Registrar, Obstetrics and Gynaecology Jessop Hospital ,Sheffield – Bassetlaw rotation
• 1.8.93 – 30.4.94 Experienced Senior House Officer, Obstetrics and Gynaecology Jessop Hospital for Women, Sheffield
• 1.8.92 – 31.7.93 Senior House Officer, Obstetrics and Gynaecology Jessop Hospital for Women, Sheffield
• 25.11.91 – 24.5.92 Senior House Officer, Obsterics and Gynaecology Chase Farm Hospital, Enfield
• 1.3.86 – 28.2.87 House Surgeon (pre-registration)
• 1.3.87 – 1.5.90 Junior Resident, Obstetrics and Gynaecology. These posts were held at the Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
• 1.8.90 – 31.7.91 Senior House Officer, Neonatology Medical College, Jammu, India

National Roles

• Chair of the British Fertility Society. I lead this professional body, which represents fertility professionals of all disciplines. This role requires me to liaise with government departments, HFEA, other professional and patient bodies and media. I chair an executive committee with 28 members.
• Member of the NICE Guideline Committee for Fertility. I am early member of this group which is developing evidence-based guidance that will be crucial for UK and international practice.
• Co-opted member of the Scientific and Clinical Advances Advisory Committee of the Human Fertilization and Embryology Authority. I provide clinical input into assessing recent advances, add-on treatments and novel technologies.
• Member of the Legislative Reform Advisory Group, HFEA
• Co-chair of the joint ARCS/BFS Working Group on Covid-19
• Member of the Advisory Board of Fertility Network UK.

Clinical Skills

• Assisted Conception : I have a wide experience of assisted conception practice. I have particular expertise in prevention and management of Ovarian Hyperstimulation Syndrome, with a record of research and national guidelines
• Reproductive Endocrinology: I am competent in managing patients presenting with a range of reproductive endocrine disorders, including polycystic ovaries, insulin resistance, hyperprolactinaemia, hypogonadotrophic hypogonadism and ovarian failure.
• Reproductive Surgery : I operate on patients with endometriosis and am able to perform ureteric and para-rectal dissection and treatment of deep disease where indicated. I perform a range of other reproductive surgery, including open myomectomy and procedures for menstrual dysfunction. I am skilled in surgical termination of pregnancy.
• Emergency Gynaecology: I am able to manage Early Pregnancy and Acute Gynaecology problems, including ectopic pregnancy and ovarian cyst accidents.
• Obstetrics : Providing support to consultant colleagues faced with significant haemorrhage, surgical difficulty and need for obstetric hysterectomy.

RESEARCH

My research interests are primarily in clinical Reproductive Medicine. I have been awarded the degree of M.D. by Bristol University for my work entitled ‘The aetiopathogenesis of ovarian hyperstimulation syndrome (OHSS) in women undergoing assisted conception’. The process of doing my M.D. has allowed me to gain experience in planning and conducting studies and critically evaluating data and literature. Work from my M.D. has been published in peer-reviewed journals and has been presented at several learned conferences (see below). I am a co-applicant in an NIHR-funded randomised controlled trial on the management of OHSS entitled STOP-OHSS. I have experience of supervising junior colleagues in carrying out clinical research projects which have been presented to learned conferences.

GCP Training 20th Sept 2020

MANAGEMENT AND CLINICAL LEADERSHIP

I have a deep interest in medical management and the pursuit of clinical excellence by individuals and institutions. Soon after my appointment as consultant I completed a course for Senior Clinical Leaders, designed to support the development of leadership skills among clinicians in Cambridge University Hospitals Foundation Trust. In 2012 I completed the NHS Clinical Leaders Network Eminent Leaders leadership development programme. This approached the subject from a foundation of psychological performance theory and included modules on Understanding your leadership style, Changing leadership behaviours, Long-term planning and Debriefing.

I was Clinical Director for Gynaecology in Addenbrooke’s Hospital for 3 years (April 2009 – June 2012). In this role I was responsible for ensuring clinical effectiveness in Gynaecology. My role included both the operational working of the Gynaecology Division and contributing to its strategic plans. As ‘first among equals’ among 12 gynaecologists, I led the division in delivering operational targets, efficiencies and service reconfiguration. I had overall responsibility for ensuring evidence-based guidelines and protocols and effective clinical audit. I supported the introduction of a robust, open clinical governance culture which has developed and matured over the years into an excellent resource for improving patient safety and quality of care. I carried out appraisal and job planning for consultant colleagues.

INVITED LECTURES (2018-2023)

• January 2023 ‘OHSS: Still a Challenge in Modern Practice’ Inaugural FOGSI-BOGS Dr Subhas Mukherjee Memorial Lecture, Kolkata, India
• January 2023 ‘Frozen versus Fresh, Day 3 versus Day 5: What is the evidence?’ All India Congress of Obstetrics and Gynaecology, Kolkata, India
• December 2022 ‘OHSS – Learning From Each Other To Keep Patients Safe’ Fertivision 2022, Hyderabad, India
• December 2022 ‘Endometriosis Surgery In Women Preparing For IVF’ Fertivision 2022, Hyderabad, India
• June 2022 ‘Regulation and Funding of IVF’ BFS Study Day for General Practitioners
• May 2022 ‘In-vitro Fertilisation Process’ Seminar on Multiple Sclerosis and Fertility
• December 2021 ‘Help us to help our patients: how clinics and the regulator can work together.’ Annual meeting of the Progress Educational Trust.
• December 2021 ‘FSH dose adjustment during ovarian stimulation’ Symposium at Controversies in Obstetrics, Gynaecolgy and Infertility, Berlin (online)
• December 2021 ‘Crisis Management in fertility- What have we learnt from the COVID-19 pandemic?’ Oration at the Annual Conference of the Inidan Fertility Society Fertivision 2021
• November 2021 Debate ‘Endometriosis should be surgically treated prior to IVF’ Annual Conference of the International Society for Reproductive Surgery
• January 2021 ‘Luteal phase support – do we know it all?’ EHSRE Campus Workshop on Success in ART (online)
• December 2020 ‘Clinical Applications of GnRH agonist trigger: efficacy and safety’ Fertivision 2020 (online)
• June 2020 ‘Learning form incidents in clinical practice’ BFS HFEA Effective Fertility Services Day (online)
• December 2019 ‘Management of infertility in women with PCOS’ IFFS-IFS joint workshop, New Delhi
• December 2019 ‘Appropriate drug selection and dosing in ovarian stimulation’ IFFS-IFS joint workshop, New Delhi
• December 2019 ‘Management of poor responders’ IFFS-IFS joint workshop, New Delhi
• December 2019 ‘Add-ons in assisted conception: how should we approach them?’ Fertivision 2019 New Delhi
• November 2019 ‘Stimulation and triggering strategies in the context of segmentation’ Merck Masterclass, York
• November 2019 ‘To minimize risk of OHSS the freeze-all decision should be made prior to commencing gonadotrophin stimulation’ Stand-Alone Meeting on Infertility Treatment, Budapest
• June 2019 ‘Dealing with incidents: Case reports from a clinical practice’ HFEA-BFS Effective Fertility Services Day, London
• September 2018 ‘Management of anovulation’ Joint meeting of the International Federation of Fertility Societies and Baltic Fertility Society, Tartu, Estonia
• September 2018 ‘Male and female work-up and stimulation regimes for IVF’ Joint meeting of the International Federation of Fertility Societies and Baltic Fertility Society, Tartu, Estonia
• February 2018 ‘Meeting the challenge of OHSS in modern reproductive practice’ Indian Society for the Study of Reproduction and Fertility meeting, Hyderabad
• January 2018 Use of adjuvants in fertility treatment. Fertility 2018, Liverpool
• January 2018 OHSS and the Daily Mail – evidence-based fact or sensationalist hype? Fertility 2018, Liverpool

PUBLICATIONS

Guidelines

• Joint ARCS BFS Best practice guidelines for reintroduction of routine fertility treatments during the COVID-19 pandemic 2020 https://www.britishfertilitysociety.org.uk/wp-content/uploads/2020/05/ARCS-BFS-COVID-19-guideline-v1.1-1.pdf
• Fertility preservation for medical reasons in girls and women: British fertility society policy and practice guideline 2018 Human Fertility 21(1):1-24
• Management of Ovarian Hyperstimulation Syndrome RCOG 2016 (Lead Author)

Book

• Reducing Risk in Fertility Treatment ed. R Mathur Springer publications ISBN 978-1-4471-5257-6

Peer-reviewed articles

• Maheshwari A, Bell JL, Bhide P, Mathur R et al (2021) Freezing All Embryos Versus Fresh Embryo Transfer in In-Vitro Fertilisation – a Multicentre Randomised Controlled Trial in the UK (E-Freeze). January 2021SSRN Electronic Journal. DOI: 10.2139/ssrn.3847725
• Maheshwari A, Muneer A, Lucky M, Mathur R, McEleny K on behalf of British Association of Urological Surgeons and British Fertility Society (2020) A review of varicocele treatment and fertility outcomes. Human Fertility DOI:10.1080/14647273.2020.1785117
• Boivin J, Harrison C, Mathur R, Burns G, Pericleous-Smith A, Gameiro S (2020) Patient experiences of fertility clinic closure during the COVID-19 pandemic: appraisals, coping and emotions Human Reproduction, 35,11: 2556. https://doi.org/10.1093/humrep/deaa218
• Sood A, Goel A, Boda S, Mathur R (2020) Prediction of significant OHSS by ovarian reserve and ovarian response – implications for elective freeze-all strategy. Human Fertility 24;1-7. doi: 10.1080/14647273.2020.1809021.
• Steinke DT, Zarroug OH, Mathur R, Kendrew H, Jenkins J (2020) Qualitative risk assessment of follicle stimulating hormone injectable products. EXPERT OPINION ON DRUG DELIVERY https://doi.org/10.1080/17425247.2020.1813106.
• Nickkho-Amiry M, Horne G, Akhtar M, Mathur R, Brison DR (2019) Hydatidiform molar pregnancy following assisted reproduction J Assist Reprod Genet. 36(4):667-671. doi: 10.1007/s10815-018-1389-9.
• Gebril A, Hamoda H, Mathur R (2017) Outpatient management of severe ovarian hyperstimulation syndrome: a systematic review and a review of existing guidelines. Human Fertility http://dx.doi.org/10.1080/14647273.2017.1331048
• Joyce Harper, Emily Jackson, Karen Sermon, Robert John Aitken, Stephen Harbottle, Edgar Mocanu, Thorir Hardarson, Raj Mathur, Stephane Viville, Andy Vail and Kersti Lundin (2017) Adjuncts in the IVF laboratory: where is the evidence for ‘add-on’ interventions? Human Reproduction 32(3):485-491.
• Tan BK, Maillou K, Mathur RS, Prentice A (2013) A retrospective review of patient-reported outcomes on the impact on quality of life in patients undergoing total abdominal hysterectomy and bilateral salpingo-oophorectomy for endometriosis. EJOGRB 170; 533-538.
• Palep-Singh M, Angala P, Seela R, Mathur R (2007) Impact of microwave endometrial ablation in the management of subsequent unplanned pregnancy J Minim Invasive Gynecol. 14(3):365-6.
• Pashayan N, Lyriatzopoulos G, Mathur R (2006) Cost-effectiveness of primary offer of IVF vs. primary offer of IUI followed by IVF (for IUI failures) in couples with unexplained or mild male factor subfertility. BMC Health Services Research 2006, 6:80 doi:10.1186/1472-6963-6-80.
• Mathur RS, Hayman G, Bansal AS, Jenkins JM (2002) Serum Vascular Endothelial Growth Factor levels in highly responsive women are poorly predictive of subsequent Ovarian Hyperstimulation Syndrome. Fertility and Sterility 78, 1154-1158.
• Mathur RS, Akande AV, Keay SD, Hunt LP, Jenkins JM (2000) Distinction between early and late OHSS. Fertility and Sterility 73, 901-912.
  Emovon E, Mathur RS, Wilson P, Ashcroft S A, Jenkins JM, Gordon U D (2000) Norethisterone cotreatment with buserelin is associated with a low incidence of functional ovarian cysts. Reproductive Technologies, 10, 206-209.
• Smith MP, Mathur RS, Keay SD, Hall L, Hull MGR, Jenkins JM (2000). Periovulatory human oocytes, cumulus cells and ovarian leukocytes express type 1 but not type 2 11 hydroxysteroid dehydrogenase RNA. Fertility and Sterility, 73, 825 – 830.
• Mathur RS, Joels LA, Jenkins JM (1995) Ovarian hyperstimulation syndrome may be more likely if multiple pregnancy follows assisted conception. Acta geneticae medicae et gemellologiae 44; 233-235.
• Lloyd-Williams, Jenkins JM, Mathur RS, Cooke ID, Morris HJ (1994) Knowledge discovery in an infertility database using artificial neural networks. Proceedings of the Institute of Electrical Engineers.

Editorials and Reviews

• Tan B, Mathur R (2014) Prevention of Ovarian Hyperstimulation Syndrome. Produced on behalf of the BFS Policy and Practice Subcommittee Human Fertility
• Tan B, Mathur R (2013) Management of Ovarian Hyperstimulation Syndrome Guidelines. Produced on behalf of the BFS Policy and Practice Committee Human Fertility Vol. 16, No. 3, Pages 160-161
• Tan B, Mathur R (2013) Management of ovarian hyperstimulation syndrome. Produced on behalf of the BFS Policy and Practice Committee Human Fertility, Vol. 16, No. 3, Pages 151-159
• Prakash A, Mathur RS (2013) Ovarian Hyperstimulation Syndrome. The Obstetrician and Gynaecologist Vol 15, 31-35.
• Prasannan-Nair, Manis T, Mathur R (2010) Management of endometriosis-associated infertility TOG Vol 13, 1-6
• Prakash A, Karasu T, Mathur R (2009) Ovarian hyperstimulation syndrome: pathophysiology, prevention and management. Obstetrics, Gynaecology and Reproductive Medicine (2009), doi:10.1016/j.ogrm.2009.05.003
• Mathur R, Sumaya W (2007) Prevention and management of ovarian hyperstimulation syndrome. Obstetrics, Gynaecology and Reproductive Medicine. 18; 18-22
• Mathur R, Kailasam C, Jenkins JM (2007) The evidence base of strategies for the prevention of OHSS. Human Fertility 10(2); 75-85
• Park S-M, Mathur R, Smith GCS (2006) Congenital anomalies after treatment for infertility. BMJ 333; 665-6
• Mathur R, Smith SK (2002) Endometrial angiogenesis – physiology and clinical implications. Journal of Family Planning and Reproductive Health Care, 28, 173-174.
• Mathur RS, Evbuomwan I, Jenkins JM (2002) Prevention and management of OHSS. Current Obstetrics and Gynaecology, 12, 111-116.
• Mathur RS, Jenkins JM (2001) Ovarian hyperstimulation Syndrome: an endocrinopathy? Current Opinion in Obstetrics and Gynaecology 13, 329-333
• Mathur RS, Jenkins JM (2000) Is Ovarian Hyperstimulation Syndrome associated with poor obstetric outcome? British Journal of Obstetrics and Gynaecology, 107, 943-946.
• Mathur RS, Jenkins JM (1999). Patients should be allowed to choose between the morbidity of OHSS and the benefits of parenthood. Human Reproduction, 14, 2183 – 2185.
• Mathur RS, Hull MGR (1998) Ovarian hyperstimulation syndrome in early pregnancy. RCOG Dialogue.
• Jenkins JM, Mathur RS (1998) Management of ovarian hyperstimulation syndrome. RCOG PACE review.
• Mathur RS, Jenkins JM, Bansal AS (1997) The possible role of the immune system in the aetiopathogenesis of ovarian hyperstimulation syndrome. Human Reproduction 12, 2629 – 2634
• Jenkins JM, Missou H, Mathur RS (1997) ReproMed – an interactive guide to Reproductive Medicine. Interact, 14, 16.
• Ford WCL, Mathur RS, Hull MGR (1997) Intra-uterine insemination for male infertility: is it effective treatment? In Baillieres Clinical Obstetrics and Gynaecology Male Infertility, Eds. van Steirteghem A, Tournaye H, Devroey P 691 – 710.
• Keay SD, Liversidge NH, Mathur RS, Jenkins JM (1997) Assisted conception following poor ovarian response to gonadotrophin stimulation. British Journal of Obstetrics and Gynaecology 104; 521 – 527.
• Mathur RS, Joels LA, Akande AV, Jenkins JM (1996) Prevention of ovarian hyperstimulation syndrome. British Journal of Obstetrics and Gynaecology 103; 740-746.
• Akande AV, Mathur RS, Keay SD, Jenkins JM (1996) The choice of luteal support following pituitary downregulation, controlled ovarian hyperstimulation and in vitro fertilization. British Journal of Obstetrics and Gynaecology 103; 963 – 966.
• Jenkins JM, Mathur RS, Cooke ID (1995) Management of severe ovarian hyperstimulation syndrome. British Journal of Obstetrics and Gynaecology 102; 2-5.
• Duncan WC, Jenkins JM, Mathur RS, Li TC (1994) Induction of ovulation by human menopausal gonadotrophins. Contemporary reviews in Obstetrics and Gynaecology 6; 154-160

Book Chapters

• Mathur R There Is No Place for Natural and Mild Stimulation IVF – For In 50 Big Debates in Reproductive Medicine eds Homburg R, Casper R and Balen A. ISBN 9781108986601
• Isdale M, Mathur R Egg Donation and Surrogacy in Problem Solving in Cancer and Fertility eds Karapanagiotou EM et al EBN Health pp 43-49.
• Mathur RS Ovarian Hyperstimulation Syndrome in Assisted Reproductive Technology ed S Bhattacharya. Future Science Group
• Mathur RS, Fox R (2002) Bilateral oophorectomy and hormone replacement therapy in women with endometriosis. In Studd JW ed., Progress in Obstetrics and Gynaecology Vol 15, 333-344

Case Reports and Letters

• Mathur R, Jenkins JM (2009) Towards a clinically useful classification of OHSS RBM Online Vol 19. No 3. 2009 434 www.rbmonline.com/Article/4619 on web 11 August 2009
• Choong CK, Calvert PA, Falter F, Mathur R, Appleton D, Wells FC, Schofield PM, Crawford R (2008) Life Threatening Impending Paradoxical Embolus Caught Red Handed: Successful Management By Multidisciplinary Team Approach Journal of Thoracic and Cardiovascular Surgery (in press)
• Mathur RS, Jenkins JM (2000) Selection of controls for study of pregnancy outcome in cycles complicated by OHSS. Fertility and Sterility 73, 123.
• Mathur RS, Oumachigui A (1991) Squamous cell carcinoma cervix with mucinous cystadenocarcinoma of the ovary – a Case Report. Journal of Gynaecology and Obstetrics of India 41; 429.

Presentations and Posters

• Mathur RS (2005) IUI after NICE – a role for cautious ovarian stimulation? Presented at the BFS annual meeting, Warwick.
• Mathur RS (2005) International variation in management of OHSS. Serono Symposium on international variation in assisted reproduction practice and data collection, Athens.
• Prentice A, Mathur RS, Morton N (2001) Superovulation improves pregnancy rates in women who fail to conceive with donor insemination alone. IFFS, Melbourne.
• Mathur RS, Hayman G, Bansal AS, Jenkins JM (2001) Serum Vascular Endothelial Growth Factor levels in highly responsive women are poorly predictive of subsequent Ovarian Hyperstimulation Syndrome. Annual meeting of the BFS, Belfast.
• Mathur RS, Bansal AS, Jenkins JM (2000) Follicular fluid Vascular Endothelial Growth Factor (VEGF) levels in highly responsive women who subsequently develop Ovarian Hyperstimulation Syndrome (OHSS) are lower than levels in matched controls – a pilot study. Winter meeting of the BFS, London.
• Mathur RS, Jenkins JM (2000) Obstetric outcome of pregnancies complicated by OHSS. Winter meeting of the BFS, Bath.
• Mathur RS, Hunt LP, Hull MGR, Jenkins JM (1999) OHSS in women undergoing assisted conception occurs in two distinct forms. Blair Bell Research Society Competition Meeting, RCOG, London.
• Mathur RS, Akande AV, Jenkins JM (1999) The occurrence of OHSS is not determined by early luteal serum hCG levels. 15th Annual meeting of ESHRE, Tours, France.
• Mathur RS, Ashcroft SA, Smith MP, Jenkins JM (1998) Functional ovarian cysts seldom occur following Gonadotrophin releasing hormone agonist with norethisterone co-treatment prior to IVF. British Fertility Society annual meeting, Sheffield.
• Keay SD, Mathur RS, Akande AV, Jenkins JM (1998) Basal serum Insulin-like Growth Factor 1 concentrations are poorly predictive of ovarian response to gonadotrophin stimulation. BFS annual meeting, Sheffield.
• Akande AV, Keay SD, Mathur RS, Jenkins JM, Hull MGR (1998) Luteal phase serum progesterone levels are poor predictors of pregnancy after IVF or GIFT treatment. BFS annual meeting, Sheffield.
• Keay SD, Mathur RS, Jenkins JM (1998) Glucocorticoid cotreatment reduces cycle cancellation due to poor ovarian response in stimulated IVF cycles. National Ovarian Workshop, Bristol.
• Mathur RS, Akande AV, Keay SD, Harbottle SJ, Jenkins JM (1997) Late onset Ovarian Hyperstimulation Syndrome in women undergoing assisted conception is poorly predicted by peak oestradiol levels and number of eggs obtained. Annual conference of ESHRE, Edinburgh.
• Mathur RS, Akande AV, Sowter M, Gordon UD, Jenkins JM, Hull MGR (1997) The antecedents of early versus late Ovarian Hyperstimulation Syndrome in women undergoing assisted conception. Joint Fertility Societies Meeting, York.
• Akande AV, Keay SD, Mathur RS, Sowter M (1997) The practical implication of a raised basal serum FSH level on the chance of poor ovarian response and cancellation of IVF treatment. Joint Fertility Societies Meeting, York.
• Keay SD, Liversidge NH, Mathur RS, Jenkins JM (1997) Ovarian follicular capacity indicated by the response to administered gonadotrophin relates to the ability of the resulting embryos to implant. Joint Fertility Societies Meeting, York.
• Mathur RS, Joels LA, Jenkins JM (1996) Ovarian Hyperstimulation Syndrome may be more likely if multiple pregnancy follows assisted conception. 3rd International meeting of the RCOG, New Delhi, India.
• Keay SD, Rennie A, Liversedge NH, Mathur RS, Akande V, Jenkins JM (1996) Reliability of IVF databases – suggestions for improvements. Winter meeting of the BFS, Cardiff.
• Mathur RS, Duncan WC, Casey SF, Jenkins JM, Cooke ID (1995) Low dose gonadotrophin therapy to improve pregnancy rates in women who fail to conceive with donor insemination alone. British Congress of Obstetrics and Gynaecology, Dublin.